CORESTA Congress, 9-13th October 2016, Germany
Poster No:STPOST34

Thorne, D¹., Crooks, I¹., Hollings, M²., Seymour, A²., Meredith, C¹., Ga
a, M¹.

¹ British American Tobacco, R&D Centre, Southampton, SO15 8TL, UK

² Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire HG3 1PY, UK.

The Aim of this study was to assess the mutagenicity of an e-cigarette aerosol, compared to cigarette smoke in tester strains TA98 and TA100 using two different exposure matrices, TPM/eTPM (or ACM – aerosol collected matter) and whole aerosol. A Vitrocell® VC 10 Smoking Robot was used to generate aerosol streams from a traditional reference cigarette (3R4F) and e-cigarette (Vype® ePen). 

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After a successful User Group Meeting 2015 in the EUROPA-PARK in Germany, International scientists from Europe, Japan and USA followed the invitation of VITROCELL® Systems to the 2016 User Group Meeting.

It offered an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange experiences in working with VITROCELL® devices and to meet fellow researchers. The meeting took place prior to the international Society of Toxicology 55th Annual Meeting and ToxExpo – one of the largest international conferences related to toxicology.

The focus of the event was to present new routes dosimetry, to give an update on VITROCELL’s participation in major European research programs related to nanoparticles as well as the presentation of new products for 2016.

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Volume 769, 15 July 2014, Pages 20–28, [epub ahead of print]

Authors
Joanne Kilford^a, David Thorne^b, Rebecca Payne^a, Annette Dalrymple^b, Julie Clements^a, Clive Meredith^b, Debbie Dillon^b

^a Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK
^b British American Tobacco, Group R&D, Southampton, Hampshire SO15 8TL, UK

Successfull modifikation of the Ames assay for the testing of a mainstream cigarette smoke aerosol that is generated with a VC 10® exposure system. The reproducebility of the response on a second VC 10® system is shown.

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24-27 March, 2014

Authors
Leverette, R.D., Misra, M., Cooper, B.T. and Bennett, M.B.

Lorillard Tobacco Company, A.W. Spears Research Center, Greensboro, NC 27405, USA

Exposition of tobacco and e-cigarette smoke, that were smoked on a VC 10® smoking robot in combination with a Vitrocell laser photometer for caculation of the delivered dose. The cytotoxicity was measured in four different endpoints: AMES, NRU, IL-8 Release and Micronucleus Assay.

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March 10-14, 2013

Authors
David Thorne¹, Joanne Kilford², Rebecca Payne², Jason Adamson¹, Ken Scott¹, Annette Dalrymple¹, Clive Meredith¹, Debbie Dillon¹

¹ Group R&D, British American Tobacco, Southampton, United Kingdom
² Covance Laboratories Ltd, Harrogate, North Yorkshire, United Kingdom

This poster shows the exposition of whole smoke on Balb/c 3T3-cells for the NRU assay and on Salmonella thyphimurium for the AMES assay by using a Vitrocell® VC 10 Smoking Robot and four quartz crystal microbalances installed into a  Vitrocell® exposure module.

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