https://doi.org/10.1016/j.toxrep.2018.04.003

Kathy Fowler^a, Wanda Fields^a, Victoria Hargreaves^b, Lesley Reeve^b, Betsy Bombick^a,
^a RAI Services Company, Scientific & Regulatory Affairs, 401 North Main Street, Winston-Salem, NC 27101, USA2
^b Covance Laboratories Ltd., North Yorkshire, UK

The article shows the successfull qualification of the Vitrocell VC10 smoking robot. The robot was used to  expose bacterial cells to cigarette whole smoke generated from 3R4F reference cigarettes and Eclipse cigarettes. A comparison was made between whole smoke from a tobacco heating and a combustible cigarette.

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https://doi.org/10.1016/j.mrgentox.2018.01.008

D. Thorne^a, M. Hollings^b, A. Seymour^b, J. Adamson^a, A. Dalrymple^a, M. Ballantyne^b, M. Gaca^a

^a British American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK
^b Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK

This study investigated the in vitro mutagenicity of e-cigarettes and designed a study to deliver e-cigarette aerosol on an undiluted per puff basis under extreme testing conditions, using the Ames assay across a broader range of bacterial tester strains. The Vitrocell VC 10 smoking robot, previously used to generate and dilute cigarette smoke aerosols was modified to enable the testing of an undiluted e-cigarette aerosol.

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CORESTA Congress, 9-13th October 2016, Germany
Poster No:STPOST34

Thorne, D¹., Crooks, I¹., Hollings, M²., Seymour, A²., Meredith, C¹., Ga
a, M¹.

¹ British American Tobacco, R&D Centre, Southampton, SO15 8TL, UK

² Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire HG3 1PY, UK.

The Aim of this study was to assess the mutagenicity of an e-cigarette aerosol, compared to cigarette smoke in tester strains TA98 and TA100 using two different exposure matrices, TPM/eTPM (or ACM – aerosol collected matter) and whole aerosol. A Vitrocell® VC 10 Smoking Robot was used to generate aerosol streams from a traditional reference cigarette (3R4F) and e-cigarette (Vype® ePen). 

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After a successful User Group Meeting 2015 in the EUROPA-PARK in Germany, International scientists from Europe, Japan and USA followed the invitation of VITROCELL® Systems to the 2016 User Group Meeting.

It offered an excellent opportunity to discuss the latest developments of VITROCELL®, to exchange experiences in working with VITROCELL® devices and to meet fellow researchers. The meeting took place prior to the international Society of Toxicology 55th Annual Meeting and ToxExpo – one of the largest international conferences related to toxicology.

The focus of the event was to present new routes dosimetry, to give an update on VITROCELL’s participation in major European research programs related to nanoparticles as well as the presentation of new products for 2016.

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Volume 769, 15 July 2014, Pages 20–28, [epub ahead of print]

Authors
Joanne Kilford^a, David Thorne^b, Rebecca Payne^a, Annette Dalrymple^b, Julie Clements^a, Clive Meredith^b, Debbie Dillon^b

^a Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK
^b British American Tobacco, Group R&D, Southampton, Hampshire SO15 8TL, UK

Successfull modifikation of the Ames assay for the testing of a mainstream cigarette smoke aerosol that is generated with a VC 10® exposure system. The reproducebility of the response on a second VC 10® system is shown.

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