Smallest nebulization volumes and high deposition efficiency

The VITROCELL® Cloud Alpha MAX is designed for small nebulization volumes and very high deposition efficiency. This is important when only small quantities of material are available or when expensive test substances need to be tested.

VITROCELL® Cloud Alpha MAX – Ideal for small quantities of test substance

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https://doi.org/10.3390/nano11010065

Silvia Diabaté ¹, Lucie Armand ², Sivakumar Murugadoss ¹ , Marco Dilger ¹ , Susanne Fritsch-Decker ¹, Christoph Schlager ³, David Béal ², Marie-Edith Arnal ², Mathilde Biola-Clier ², Selina Ambrose ⁴, Sonja Mülhopt ³, Hanns-Rudolf Paur ³, Iseult Lynch ⁵ , Eugenia Valsami-Jones ⁵ , Marie Carriere ², and Carsten Weiss ¹

¹ Karlsruhe Institute of Technology, Institute of Biological and Chemical Systems–Biological Information Processing, 76344 Eggenstein-Leopoldshafen, Germany;
² CEA, CNRS, IRIG, SyMMES, University Grenoble Alpes, 38054 Grenoble, France;
³ Karlsruhe Institute of Technology, Institute for Technical Chemistry, 76344 Eggenstein-Leopoldshafen, Germany; 
⁴ Promethean Particles Ltd., Nottingham NG7 3EF, UK;
⁵ School of Geography Earth & Environmental Sciences (GEES), University of Birmingham (UoB), Edgbaston, Birmingham B15 2TT, UK;

KIT, together with VITROCELL SYSTEMS, set up a first Automated Exposure Station, which has been used for the assessment of nanoscale particle emissions from combustion sources such as ship diesel and wood burners. The system was further developed and offers a compact solution for toxicity testing of nanoparticle (NP) aerosols including sample conditioning, reproducible deposition, integrated dose determination by a quartz crystal microbalance (QCM), flow control, automated processes and data acquisition. The device was also tested with partner laboratories with the aim of potentially standardizing and achieving regulatory acceptance of the method.

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doi:10.3390/nano10122369

Lars B. Leibrock ¹, Harald Jungnickel ¹, Jutta Tentschert ¹, Aaron Katz ¹, Blaza Toman ² , Elijah J. Petersen ³ , Frank S. Bierkandt ¹, Ajay Vikram Singh ¹ , Peter Laux ¹ and Andreas Luch ^1
1 German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany; 
² Information Technology Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaitherburg, MD 20899-8311, USA; 
³ Materials Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaitherburg, MD 20899-8311, USA; 

ALI systems are considered to be a promising exposure system to study toxicological e ects of airborne nanomaterials instead of in vivo inhalation studies and have been widely used to assess the toxicology of nanomaterials in recent years. However, the robustness of these methods is not yet wellunderstood. Here we reported a C&E analysis of a commonly used flow through ALI exposure system.

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https://doi.org/10.1016/j.toxlet.2020.11.006

Albert Giralt^a, Anita R Iskandar^a, FlorianMartin^a, ElisaMoschini^b, TomassoSerchi^b, AthanasiosKondylis^a, DiegoMarescotti^a, PatriceLeroy^a, LauraOrtega-Torres^a, ShoaibMajeed^a, CelineMerg^a, KeyurTrivedi^a, EmmanuelGuedj^a,StefanFrentzel^a, Nikolai V Ivanov^a, Manuel C Peitsch^a, Arno C Gutleb^b, JuliaHoeng^a

^a Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland
^b Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology, Luxembourg

Highlights
• Biological impact of exposure to an aerosol of an e-vapor device was investigated using human bronchial and alveolar models.
• The biological impact of e-vapor aerosol exposure was lower than that of cigarette smoke at similar nicotine levels.
• The exposure effects at the molecular levels were evaluated using a systems toxicology approach.

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DOI: 10.1002/jat.4113

Clémence Méausoone¹, Yann Landkocz¹, Fabrice Cazier², Marianne Seigneur¹ Dominique Courcot¹, Sylvain Billet^1
1Unité de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 3417, Université du Littoral Côte d'Opale, Dunkirk, France
²Centre Commun de Mesures, Université du Littoral Côte d'Opale, Dunkirk, France

Benzene and toluene are solvents largely used in industries and emitted into the atmosphere, despite major and direct impacts on human health. This study shows the feasibility of observing mechanisms of toxic action during repeated exposure at ALI to doses close to human exposure. The second strength of this study was the measure of XME induction level with the initiation of several xenobiotic metabolism pathways over time. BEAS-2B cells were exposed to benzene, toluene, m-xylene, or mesitylene gaseous stream diluted in air using the Vitrocell ALI system.

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