Advanced in vitro exposure systems.

31. Aug. 2009

WC 7 Rome

New VITROCELL® General Product Catalogue first presented at the WC7.

VITROCELL® presents key technologies for the in vitro exposure of airborne substances such as gases, complex mixtures, nano particles and fibres at the WC7 World Congress on Alternatives and Animal Use in the Life Sciences. The Congress is taking place in Rome from August 30 - September 3, 2009.

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Categories: Product News

Tags: inhalation exposure

23. Mar. 2009

Lung toxicity determination by in vitro exposure at the air-liquid interface with an integrated online dose measurement

Nanosafe 2008: International Conference on Safe production and use of nanomaterials

Journal of Physics: Conference Series 170 (2009) 012008 (doi:10.1088/1742-6596/170/1/012008)

Authors
Sonja Mülhopt, S. Diabaté, T. Krebs, C. Weiss and H.-R. Paur

Institute for Technical Chemistry, Thermal Waste Treatment Division, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe GmbH, Karlsruhe, Germany
VITROCELL Systems GmbH, 79183, Waldkirch, Germany

 

Human lung cell cultures are exposed to airborne nanoparticles in VITROCELL®system modules. After exposure the cells are analyzed to measure the biological responses of the viability (LDH, AlamarBlue) as well as the release of IL-8. Using fluorescein sodium particles shows a very good correlation between the sensor signal of the quartz crystal microbalance and the deposited mass on the membranes shown by spectroscopy. This system for the first time provides an online dose measurement for in vitro experiments with nanoparticles. 

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19. Mar. 2009

Identification of Indoor Air Contaminants Using an in Vitro Exposure System

SOT Baltimore, USA

March 15-19, 2009

Authors
Laurel G. Jackson, J. R. Wells, Jason Ham, Albert Munson, and Stacey E. Anderson

National Institute for Occupational Safety and Health, (CDC-NIOSH), Morgantown, USA

 

A549 cells were exposed to volatile organic compounds in the air-liquid interface. The results are measured in RNA isolation and  gene expression analysis.

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31. Oct. 2008

EUROTOX

45th Congress of the European Societies of Toxicology in Rhodes, Greece from October 5-8, 2008

The VITROCELL® in vitro test systems for the analysis of the effects of nanoparticles and airborne pollutants found strong interest during EUROTOX 2008. Now online dose determination is possible via an integrated Quartz Crystal Microbalance (QCM).

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8. Oct. 2008

Online dose determination for in vitro experiments with nano particles in the Karlsruhe Exposure System

EUROTOX. Rhodes, Greece.

October 5-8, 2008

Authors
S. Mülhopt, H.-R. Paur, T. Krebs

Forschungszentrum Karlsruhe, Eggenstein – Leopoldshafen, Germany
VITROCELL Systems GmbH, Waldkirch, Germany

 

Poster about the exposition of airborne nanoparticles to human lung cell cultures in VITROCELL®system modules. After exposure the cells are analyzed to measure the biological responses of the viability (LDH, AlamarBlue) as well as the release of IL-8. Using fluorescein sodium particles shows a very good correlation between the sensor signal of the quartz crystal microbalance and the deposited mass on the membranes shown by spectroscopy. This system for the first time provides an online dose measurement for in vitro experiments with nanoparticles. 

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6. Aug. 2008

News Release

New VITROCELL® cigarette smoking machine for puff by puff analysis

The new development opens up advanced possibilities for research.

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30. Mar. 2008

SOT Meeting Seattle

VITROCELL® SYSTEMS reports increasing interest in aerosol generators and biological test systems for nano particles at the 2008 SOT Annual Meeting

VITROCELL presents the direct exposure technology for the in vitro analysis of airborne substances such as gases, nano particles and complex mixtures.

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Categories: Product News

Tags: inhalation exposure

10. Mar. 2008

The Response of a Co-culture Lung Model to Fine and Ultrafine Particles of Incinerator Fly Ash at the Air-liquid Interface

ATLA

ATLA, Issue 36, pp. 285-298, 2008

Authors
Silvia Diabaté, Sonja Mülhopt, Hanns-Rudolf Paur and Harald F. Krug

Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein - Leopoldshafen, Germany

 

BEAS-2B cells were exposed to an aerosol, generated from fly ash. The cells were co-cultured with differentiated THP-1 macrophages growing on Transwell inserts. Analyses of cell viability and IL-8 release were performed.

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10. Mar. 2008

Exposure of a multi-cellular in vitro model of human airway tissue to the whole cigarette smoke

Respiratory and Critical Care Medicine

Vol 177 (Abstracts Issue): pA728 (2008)

Authors
Walsh, P.T., Chalupowicz, D.G., Frankowski, R., Barnette, M.

Discovery Biology, Respiratory CEDD, GlaxoSmithKline, Upper Merion, PA19406, USA

 

HBE cells were exposed in a single and repeated whole smoke situation. The cells were analysed for changes in gene expression (RT-PCR) and cell viability was confirmed using the MTT assay and release of IL-1, IL-6 and IL-8.

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10. Mar. 2008

Cellular responses of primary human bronchial epithelial cells to whole cigarette smoke exposure

Respiratory and Critical Care Medicine

Vol 177 (Abstracts Issue): pA199 (2008)

Authors
Chalupowicz, D.G., Frankowski, R., Sanchez, Y., Kou, J., Barnette, M., and Walsh, P.T.

GlaxoSmithKline


Primary human bronchial epithelial cells were exposed in a single and repeated whole smoke situation. The cells were analysed for changes in gene expression (RT-PCR) and cell viability was confirmed using the MTT assay and release of IL-1, IL-6 and IL-8.

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