DOI: 10.1016/j.yrtph.2019.01.036

Czekala L¹, Simms L², Stevenson M², Tschierske N², Maione AG³, Walele T².
¹ Imperial Brands PLC, 121 Winterstoke Road, Bristol, BS3 2LL, UK. Electronic address: Lukasz.Czekala@uk.imptob.com.
² Imperial Brands PLC, 121 Winterstoke Road, Bristol, BS3 2LL, UK.
³ MatTek, 200 Homer Ave., Ashland, MA, USA.

In this research article a respiratory epithelial model, EpiAirway, was used to examine the biological effects of nicotine-containing blu PLUS + e-cigarettes, in comparison to conventional cigarette smoke. Tissues were exposed at the air-liquid interface to cigarette smoke or e-cigarette aerosol generated using a VITROCELL VC1 smoking/vaping robot. 

Read more

https://doi.org/10.1016/j.tiv.2018.12.010

Brian M. Keyser^a, Robert Leverette^a, Kathy Fowler^a, Wanda Fields^a, Victoria Hargreaves^b, Lesley Reeve^b, Betsy Bombick^a
a RAI Services Company1, Scientific & Regulatory Affairs, 401 North Main Street, Winston-Salem, NC 27101, USA
^b Covance Laboratories Ltd., North Yorkshire, UK

The aims of this study were to investigate dosimetry during whole smoke exposure in the VITROCELL® VC10® smoking robot using QCMs and to determine whether photometers could be used for concurrent assessment of dose during in vitro whole smoke exposures.

Read more

The Society of Toxicology 58^th Annual Meeting and ToxExpo promises stimulating lectures and presentations on scientific breakthroughs, important education and professional training opportunities, and time to connect with old friends and create new collaborations.

Read more

DOI: 10.1089/jamp.2017.1364

Ivana d’Angelo, PhD,¹ Gabriella Costabile, PhD,^2,3 Estelle Durantie, PhD,³ Paola Brocca, PhD,⁴ Valeria Rondelli, PhD,⁴ Annapina Russo, PhD,⁵ Giulia Russo, PhD,⁵ Agnese Miro, PharmD,² Fabiana Quaglia, PhD,² Alke Petri-Fink, PhD,³ Barbara Rothen-Rutishauser, PhD,³ and Francesca Ungaro, PhD^2
1 Di.S.T.A.Bi.F., University of Campania ‘‘Luigi Vanvitelli,’’ Caserta, Italy.
² Laboratory of Drug Delivery, Department of Pharmacy, University of Napoli Federico II, Napoli, Italy.
³ Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
⁴ Applied Physics, Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano, Italy.
⁵ Laboratory of Biochemistry, Department of Pharmacy, University of Napoli Federico II, Napoli, Italy.

The Vitrocell Cloud was used for the exposure to aerosolized nanoparticles on a in vitro three-dimensional cell cluture, mimicking the human epithelial airway barrier comprising human bronchial epithelial cells,human blood monocyte-derived macrophages and dendritic cells to show the optimized siRNA transport and delivery at lung.

Read more

DOI: 10.1016/j.tiv.2018.06.024

Steiner S, Diana P, Dossin E, Guy P, Vuillaume G, Kondylis A, Majeed S, Frentzel S, Hoeng J

PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuchatel, Switzerland.

Highlights
•Different smoke constituents are delivered with different efficiencies during in vitro exposures.
•This indicates considerable differences in the composition of the applied and the absorbed smoke.
•The composition of the applied smoke is of limited value for describing the exposure.

Read more