Advanced in vitro exposure systems.

13. Jun. 2017

PETA science consortium donates $400K in VITROCELL in vitro test equipment

London -- Today, the PETA International Science Consortium Ltd. announced that it is providing equipment to laboratories working on human-relevant methods to replace the use of animals in inhalation testing. Valued at more than $400,000, VITROCELL Systems inhalation exposure machines were awarded to four institutions in the U.S., U.K., and Belgium that are leading the field of in vitro (non-animal) inhalation toxicology. These donations complement the Consortium's recent workshops and webinars focused on replacing inhalation testing in animals.

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3. Jun. 2017

Delivery of glycerol-based aerosols in the Vitrocell® 24/48 aerosol exposure system

ISAM, THE 21ST INTERNATIONAL SOCIETY OF AEROSOLS IN MEDICINE CONGRESS, 03-07 June, 2017

Sandro Steiner, Shoaib Majeed, Gilles Kratzer, Mounir Rhouma, Quentin Dutertre, Grégory Vuillaume, Arno Knorr, Julia Hoeng, Stefan Frentzel

Philip Morris International R&D, Philip Morris Products S.A.

Characterization of the Vitrocell® 24/48 aerosol exposure system for its use in conjunction with liquid aerosols shows a high feasibility for an easy detection of aerosol deposition.

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3. Jun. 2017

In Vitro Testing of Aerosolized Substances with Primary 3D Human Airway Epithelia: Application of ALICE-Cloud Technology to e-liquids (e-cigarettes)

ISAM, THE 21ST INTERNATIONAL SOCIETY OF AEROSOLS IN MEDICINE CONGRESS, 03-07 June, 2017

S. Constant1, A. Stelzl2,3, O. Eickelberg2,3,4, O. Schmid2,3
1Epithelix, Genève, Switzerland
2Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany
3Institute of Lung Biology and Disease, Helmholtz Zentrum München, Munich/Neuherberg, Germany
4University Hospital of the Ludwig Maximilians University (LMU), Munich, Germany

The poster shows the ALICE-Cloud technology combined with primary ALI 3D cell cultures. The effect of nebulized e-liquids were investigated in terms of tissue integrity, celia beating frequency, mucin secretion and IL-8 secretion.

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25. May. 2017

21. ISAM-Congress

June 03–07, 2017. Santa Fe, New Mexico, USA

The ISAM Congress has developed into one of the largest pulmonary drug delivery and medical aerosol events worldwide. It offers a high-level program for scientists of different disciplines, clinicians, pharmacists and all respiratory healthcare professionals working in this area.

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Categories: Exhibitions

Tags: congress

22. May. 2017

Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures

DOI: 10.1039/c7tx00109f
Jose Zavala,a Rebecca Greenan,b Q. Todd Krantz,a David M. DeMarini,a Mark Higuchi,a M. Ian Gilmour a and Paul A. Whiteb

aNHEERL, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
bMechanistic Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada.


The aim of this study was to test whether temperature and relative humidity has an influence on the cytotoxicity to BEAS-2B cells on a VITROCELL® 6 air-liquid interface system by measuring the viability (WST-1 cell proliferation assay) and lactate dehydrogenase (LDH) release.
Note from VITROCELL: We inform our customers about the possible need for humidification during installation and training. Among the need for humidification, possible other reasons for low clean air viability are clean air quality and cell handling procedures. Please see our website chapter on humidification for further information http://www.vitrocell.com/inhalation-toxicology/humidification

 

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21. May. 2017

8th International Symposium on Nanotechnology, Occupational and Environmental Health

May 29 to June 1, 2017. Elsinore, Denmark

Building on the success of the 2015 symposium held at Legend Safari Lodge, Limpopo Province, South Africa, this conference will also bring together a multidisciplinary cross section of delegates from different scientific areas specializing in all aspects of nanosafety.

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Categories: Exhibitions

Tags: congress

15. May. 2017

Human Asthmatic Bronchial Cells Are More Susceptible to Subchronic Repeated Exposures of Aerosolized Carbon Nanotubes At Occupationally Relevant Doses Than Healthy Cells

DOI: 10.1021/acsnano.7b01992

Savvina Chortarea,1 Hana Barosova,1 Martin James David Clift,2 Peter Wick,3 Alke Petri-Fink,1,4 and Barbara Rothen-Rutishauser,1

1BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, CH-1700 Fribourg, Switzerland
2In Vitro Toxicology Group, Swansea University Medical School, Swansea SA2 8PP, Wales, U.K.
3Laboratory for Materials-Biology Interactions, Empa, Swiss Federal Laboratories for Materials, Science and Technology, 9014 St Gallen, Switzerland
4Department of Chemistry, University of Fribourg, CH-1700 Fribourg, Switzerland

The aim of this study was to realistically mimic subchronic inhalation of multiwalled carbone nanotubes in vitro, using the air−liquid interface cell exposure system for aerosol exposures on reconstituted human bronchial tissue from healthy and asthmatic donors. Cytotoxicity, cell morphology, cilia beating frequency, mucociliary clearance, gene expression analysis of oxidative stress and (pro‑)inflammatory markers as well as (pro‑)inflammatory cytokine secretion were successfully observed.

 

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1. May. 2017

Proof of Concept of the VITROCELL® Dry Powder Chamber: A New In Vitro Test System for the Controlled Deposition of Aerosol Formulations

Marius Hittinger,1 Sarah Barthold,2 Lorenz Siebenbürger,1 Kilian Zäh,3 Alexander Gress,1 Sabrina Guenther,1 Birgit Wiegand,1 Carsten Boerger,1 Markus Berger,4 Tobias Krebs,4 Henrik Groß,1 and Claus-Michael Lehr1,5

1PharmBioTec GmbH, Saarbrücken, Germany
2Saarland University, Department of Pharmacy, Saarbrücken, Germany
3Scienceneering UG, Blieskastel, Germany
4Vitrocell Systems GmbH, Waldkirch, Germany
5Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), HZI, Saarbrücken, Germany

The VITROCELL® Dry Powder Chamber is designed for aerosol deposition of different sized particles separated by their time of flight. For the development of this new instrument salbutamol sulphate was successfully exposed to human pulmonary epithelial cell culture by sedimentation and diffusion in vitro.

 

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16. Apr. 2017

4th Biological and Toxicological Conference

April 25–28, 2017. Hangzhou, China

Comments (0) Number of views (539)

Categories: Exhibitions

Tags: congress

5. Apr. 2017

7th Conference of Alternative Methods

April 11–14, 2017. Guangzhou, China

Comments (0) Number of views (375)

Categories: Exhibitions

Tags: congress

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