VITROCELL® News

9. Jul. 2018

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures.

DOI: 10.1016/j.tiv.2018.06.024

Steiner S, Diana P, Dossin E, Guy P, Vuillaume G, Kondylis A, Majeed S, Frentzel S, Hoeng J

PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000, Neuchatel, Switzerland.

Highlights
•Different smoke constituents are delivered with different efficiencies during in vitro exposures.
•This indicates considerable differences in the composition of the applied and the absorbed smoke.
•The composition of the applied smoke is of limited value for describing the exposure.

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Categories: Publications

Tags: tobacco smoke, VITROCELL 24, air-liquid Interface

6. Jul. 2018

54th Congress of the European Societies of Toxicology (EUROTOX)

September 2–5, 2018. Brussels, Belgium. Booth #24

The theme for 2018 is “Toxicology Out of the Box”. It reflects the willingness and enthusiasm to offer a really innovative, forward-looking and imaginative scientific programme.

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Categories: Exhibitions

Tags: congress

30. Jun. 2018

Characterization and modeling of aerosol deposition in Vitrocell® exposure systems - exposure well chamber deposition efficiency

DOI 10.1016/j.jaerosci.2018.06.015

Francesco Lucci^a, Nicolas D. Castro^b, Ali A. Rostami^b, Michael J. Oldham^b, Julia Hoeng^a, Yezdi B. Pithawalla^b, Arkadiusz K. Kuczaja^c

^a Philip Morris International Research & Development, Philip Morris Products S.A. (part of Philip Morris International group of companies), Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
^b Altria Client Services LLC, Center for Research and Technology, Richmond, VA 23219, USA
^c Multiscale Modeling & Simulation, Dept. of Applied Mathematics, University of Twente, P.O.Box 217, 7500 AE Enschede, The Netherlands

This paper successfully presents the geometry and characteristic dimensions of the two exposure systems: Vitrocell 24/48 and Vitrocell AMES 48. A computational modeling of aerosol transport and deposition shows the deposition efficiency.

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Categories: Publications

Tags: VITROCELL 24, AMES, air-liquid Interface

15. Jun. 2018

ACE nano: pursuing analytical and characterisation excellence in nanomaterial risk assessment

Nanomaterials are man-made materials of a size thousands of times smaller than the width of a human hair. They have fascinated scientists and industry with their unique and unpredictable properties, which have given rise to an endless variety of new applications in every sector of technology and medicine. As a result, an ever-increasing number of nanomaterials are entering the market in everyday products spanning from healthcare and leisure to electronics, cosmetics and foodstuffs. However, the novelty in exploitable properties may be mirrored by new hazards and, in order to manage these, a well-founded and robust legislative framework that will ensure safe development of nano-enabled products is needed.

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Categories: Product News

Tags: nanoparticles

6. Jun. 2018

Distribution of polymer-coated gold nanoparticles in a 3D lung model and indication of apoptosis after repeated exposure

DOI: 10.2217/nnm-2017-0358

Savvina Chortarea^1,2, Kleanthis Fytianos^1,3,4, Laura Rodriguez-Lorenzo¹, Alke Petri-Fink^1,5 & Barbara Rothen-Rutishauser¹
¹BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
²Laboratory for Particles – Biology Interactions, Empa, Swiss Federal Laboratories for Materials, Science & Technology, St Gallen, Switzerland
³Department of Pulmonary Medicine, University of Bern, Bern, Switzerland
⁴Department of Clinical Research, University of Bern, Bern, Switzerland
⁵Department of Chemistry, University of Fribourg, Fribourg, Switzerland

The distribution and impact of aerosol-delivered functionalized AuNPs upon repeated administration were explored in a complex in vitro human lung epithelial tissue barrier model applying an air–liquid interface exposure approach. Nanoparticles were aerosolized using the Air-Liquid Interface system consisting of a nebulizer, an exposure and an incubation chamber connected to an air-flow system to provide optimum conditions for cell cultivation as well as a quartz crystal microbalance for online measurements of the NP dose deposited on the cells surface.

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Categories: Publications

Tags: inhalation exposure, nanoparticles, microbalance, liquid aerosol, VITROCELL Cloud, air-liquid Interface, airborne particles

1. Jun. 2018

Charakterisierung von Partikelemissionen aus dem Trennschleifprozess von kohlefaserverstärktem Beton (Carbonbeton)

Autoren:
Hillemann, L.; Stintz, M.; Streibel, T.; Zimmermann, R.; Öder, S.; Kasurinen, S.; di Bucchianico, S.; Kanashova, T.; Dittmar, G.; Konzack, D.; Große, S.; Rudolph, A.; Berger, M.; Krebs, T.; Saraji-Bozorgzad, M. R.; Walte, A.

Die Wirkung von Emissionen aus dem Trennen von Carbonbeton werden in einer Kombination aus Trennstaubgenerator, Verdünnungssystem und Expositionssystem an Zellkulturen (A549 und THP-1) gegenüber den entstehenden Stäuben bestimmt (Zytotoxizität).

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Categories: Publications

Tags: inhalation exposure, nanoparticles, exposure station, air-liquid Interface, airborne particles

26. May. 2018

Acute effects of multi-walled carbon nanotubes on primary bronchial epithelial cells from COPD patients

DOI: 10.1080/17435390.2018.1472310

Beyeler S^1,2, Chortarea S^3,4, Rothen-Rutishauser B³, Petri-Fink A³, Wick P⁴, Tschanz SA⁵, von Garnier C^1,2, Blank F^1,2.

¹ Department of BioMedical Research , University of Bern , Bern , Switzerland.
² Department of Pulmonary Medicine , University Hospital of Bern , Bern , Switzerland.
³ BioNanomaterials, Adolphe Merkle Institute, University of Fribourg , Fribourg , Switzerland.
⁴ Laboratory for Particles-Biology Interactions, Empa Swiss Federal Laboratories for Material Science and Technology , St. Gallen , Switzerland.
⁵Institute of Anatomy, University of Bern , Bern, Switzerland.

This paper shows the investigation of acute effects of occupational multi-walled carbon nanotubes exposure in primary epithelial lung cell cultures from potentially susceptible individuals with COPD.

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Categories: Publications

Tags: inhalation exposure, nanoparticles, microbalance, liquid aerosol, VITROCELL Cloud, air-liquid Interface, airborne particles

10. May. 2018

Combining MucilAir™ and Vitrocell® Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen

https://doi.org/10.3390/pharmaceutics10020056

Julia Metz ^1,2, Katharina Knoth ¹, Henrik Groß ¹, Claus-Michael Lehr ^1,2,3, Carolin Stäbler ⁴, Udo Bock ⁵, and Marius Hittinger ¹
¹Department of Drug Delivery, PharmBioTec GmbH, 66123 Saarbrücken, Germany
²Department of Biopharmaceutics and Pharmaceutical Technology, Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany
³Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123 Saarbrücken, Germany
⁴Department of Scientific Affairs Consumer Health, Bayer Vital GmbH, 51368 Leverkusen, Germany
⁵Bock Project Management, 54456 Tawern, Germany

In this study two innovative in vitro techniques were combined: The Vitrocell® Powder Chamber and the human cell based MucilAir™ system. Their combined use allows the investigation of the effect of aerosolized pollen and appropriate drugs on a human mucosal tissue, a similar scenario finding in humans. The release of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) was quantified as an initial cellular response to pollen contact and to confirm the protective effect of drugs.

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Categories: Publications

Tags: inhalation exposure, air-liquid Interface, airborne particles, powder chamber

3. May. 2018

Application of a direct aerosol exposure system for the assessment of biological effects of cigarette smoke and novel tobacco product vapor on human bronchial epithelial cultures

https://doi.org/10.1016/j.yrtph.2018.05.004

Shinkichi Ishikawa∗, Kazushi Matsumura, Nobumasa Kitamura, Kanae Ishimori, Yuichiro Takanami, Shigeaki Ito

Scientific Product Assessment Center, R&D Group, Japan Tobacco Inc., 6-2 Umegaoka, Aoba-ku, Yokohama, Kanagawa 227-8512, Japan

The experimental setup for the aerosol exposure consisted of a VC 10 smoking robot, a dilution system, and a Vitrocell 12/3 glass module the exposure of nicotine and TPM in the mainstream aerosols from 3R4F and novel tobacco vapor on MucilAir™ cells. The results are shown in cytotoxicity, IL-8, IL-1ß and gene expression.

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Categories: Publications

Tags: inhalation exposure, tobacco smoke, e-cigarettes, VC 10 smoking robots, VITROCELL 12

20. Apr. 2018

2018 Genetic Toxicology Association Meeting (GTA)

May 3–4, 2018. Newark, USA.

The Genetic Toxicology Association (GTA) will hold its annual scientific meeting May 3-4, 2018 on the campus of the University of Delaware in Newark, DE.

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Categories: Exhibitions

Tags: congress

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September 2–5, 2018. Brussels, Belgium. Booth #24

May 3–4, 2018. Newark, USA.

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