Patrick Weindl¹, Dr. Otmar Schmid²,

¹VITROCELL Systems GmbH, 79183 Waldkirch, Germany
²Helmholtz Center Munich, Germany

The poster shows the design for smallest nebulization volumes and high deposition efficiency.

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D. Sheehan¹, M. Aragon¹, J. Adamson², M. Gaca², H. Raabe¹, and H. Behrsing¹.
¹Institute for In Vitro Sciences, Inc., Gaithersburg, MD; and 2British American Tobacco, Southampton, United Kingdom.

This study demonstrates successful Vitrocell VC1 aerosol generation and delivery across multiple nicotine product categories (3R4F cigarette smoke, e-liquid and THP), as characterised using nicotine as a dosimetry marker. The data suggests the VC1 can reproducibly generate and deliver tobacco product and NGP aerosols for future in vitro assessment and matches the performance of reported exposure systems.

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Johannes Sood
VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The poster demonstrates the new VITROCELL® Monitor software interface.

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Patrick Weindl, Oliver Wisser

VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The VITROCELL® Cloud SEQ represents another evolution of the well-known Cloud systems. Keeping functional process parameters according to established devices like the VITROCELL® Cloud 6, 12 or 24 it is meant to enhance those devices even further. lt offers the possibility to sequentially expose rows of inserts to create dose-response curves while keeping the concentration of nebulized liquid at the same level and the cell-cultures under highly comparable conditions.

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Chary A.^1,2, Serchi T.1, Cambier S.1, Moschini E.1, Contal S.¹, Hennen J.², Ezendam J.³, Blömeke B.², Gutleb A.C.^1
1 Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Luxembourg.
² Department of Environmental Toxicology, Trier University, Germany. 3Centre for Environmental Protection,National Institute for Public Health and the Environment (RIVM), The Netherlands.

Aim
- Adapt a 3D-coculture system previously developed by us (Klein et al. 2013) allowing the study of respiratory sensitization processes by including dendritic cells, which have a crucial role in sensitization
- Find markers for the assessment of the respiratory sensitizing potential of inhaled compounds by measuring the activation of DCs as well as the release of cytokines

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