Advanced in vitro exposure systems.

31. Mar. 2012

New on SOT San Francisco

VITROCELL® 12/12 Module

The new module with 12 cell culture compartments is a compact solution for exposure using 12-well or 24-well sized inserts.

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Categories: Product News

Tags: VITROCELL 12

31. Mar. 2012

New on SOT San Francisco

Smoking machine VC 1

The new smoking machine is a high quality manual smoking machine based on VC 10 technology.

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15. Mar. 2012

Dosimetry Methods for Tobacco Smoke Aersosol In Vitro Exposures

SOT San Francisco, USA

March 11-15, 2012. Poster #1841

Authors
Rainy Marsh1, Jessica Perkins2, Ken Scott2, Debbie Dillon2 and Clive Meredith2

1 British American Tobacco, Group R & D, Southampton, United Kingdom
2 Covance Laboratories Ltd., Harrogate, United Kingdom

 

Successfull experiments in dosimetry of particulate concentration entering the exposure modules to test tobacco smoke on the AMES assay.

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15. Mar. 2012

Impact of test conditions on in vitro cytotoxicity measurements of mainstream cigarette smoke using a whole smoke exposure system

SOT San Francisco, USA

March 11-15, 2012; Poster #1843

Authors
Xiang Li, Pingping Shang, Cong Nie, Fuwei Xie, Huimin Liu, Jianping Xie


Key Laboratory of Tobacco Chemistry, 

Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, China

 

This article shows the influence of whole smoke on A549 cells under ISO and HC regimen. The results are shown on the NRU assay. 

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15. Mar. 2012

Utilization of a whole smoke exposure system for the comparison of mainstream cigarette smoke, gas vapor phase and tar mutagenicity

SOT San Francisco, USA

March 11-15, 2012; Poster #1843

Authors
Robert D. Leverette

Life Sciences, A.W. Spears Research Center, Lorillard Tobacco Company, Greensboro, NC 27405, USA

 

This study was conducted to optimize smoke exposure procedures, measure the mutagenicity of mainstream cigarette whole smoke, the gas vapor phase and wet total particulate matter (WTPM) as determined by the Ames Assay.

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16. Dec. 2011

Effects of smoking regimens and test material format on the cytotoxicity of mainstream cigarette smoke

Food Chem Toxicol

2011 Dec 16; 50(3-4):545-551. [Epub ahead of print]

Authors
Li X, Shang P, Peng B, Nie C, Zhao L, Liu H, Xie J.

Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China

 

Total particulate matter or whole smoke generated from different test cigarettes under ISO or HCI regimens were assessed for cytotoxicity using the neutral red uptake cytotoxicity assay. Cytotoxicity among the test cigarettes were greater for whole smoke and the cytotoxicity was decreased going from ISO regimen to HCI regimen. 

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1. Dec. 2011

Evaluating pulmonary toxicity of engineered metal-based nanoparticles using in vivo and in vitro models

Iowa Research Online

Related Comprehensive Document: University of Iowa

Authors
Dissertation of Jong Sung Kim (2011)

University of Iowa, Iowa City, IA 52242, USA.

 

This dissertation shows the generating of nano particle aerosols and depositing them directly onto A549 cells grown at the air‐liquid interface to mimic a more realistic in vivo pulmonary exposure to inhaled nano particles.

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8. Nov. 2011

Investigations on cytotoxic and genotoxic effects of laser printer emissions in human epithelial A549 lung cells using an air/liquid exposure system

Environmental and Molecular Mutagenesis

November 8, 2011 (doi: 10.1002/em.20695)

Authors
Tang, T., Gminski, R., Könczöl, M., Modest, C., Armbruster, B. and Mersch-Sundermann, V. (2011)

Department of Environmental Health Sciences, Freiburg University Medical Center
Institut für Umweltmedizin und Krankenhaushygiene, Freiburg im Breisgau, Germany
Email: Volker Mersch-Sundermann (volker.mersch-sundermann@uniklinik-freiburg.de)

 

The cytotoxic and genotoxic effects of the emission from laser printers were investigated. Cytotoxicity was determined by the WST-1 assay and genotoxicity by the micronucleus test in human A549 lung cells.

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28. Sep. 2011

Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface

Toxicol Sci

2012 Feb;125(2):450-61 (doi:10.1093/toxsci/kfr251) [Epub ahead of print]

Authors
Xie Y, Williams NG, Tolic A, Chrisler WB, Teeguarden JG, Maddux BL, Pounds JG, Laskin A, Orr G.

Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA

 

The exposure of alveolar type II epithelial cells (C10) to aerosolized nano particles at the ALI is shown in this article. Cell proliferation, cell viability, membrane integrity and oxidative stress were used as endpoints. 

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31. Aug. 2011

Effect of Formaldehyde On Corneal Epithelial Cells In An Air-Liquid Culture Model

EUROTOX Paris, France

August 28-31, 2011; Poster #P1198

Authors
Françoise Brignole-Baudouin1,2,4, Sophie Achard3, Charles Persoz3, Alice Emptoz1,2, Nathalie Seta3, Christophe Baudouin1,2,4

1 UMR_S968 INSERM UPMC; UMR 7210 CNRS; Institut de la Vision, Paris, France
2 Laboratoire de Toxicologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes
3 Laboratoire de Santé Publique et d’Environnement, EA 4064, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes
4 Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, 75012 Paris

 

The aim of this poster is to show the inflammatory effect of gaseous formaldehyde on human corneal epithelial cells in an air-liquid culture.The Results are shown in protein assay, LDH, IL-8, MCP-1 and flow cytometry assays.

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