2014 Jun 21;229(1):144-149. doi: 10.1016/j.toxlet.2014.05.023. Epub ahead of print.

Authors
Bardet G.¹, Achard S.², Loret T.³, Desauziers V.⁴, Momas I.⁵, Seta N.⁶

¹ Université Paris Descartes, EA 4064, Laboratoire de Santé Publique et Environnement, 4, Avenue de l'Observatoire, 75006 Paris, France; Agence de l'Environnement et de la Maîtrise de l'Energie, Angers, France.
² Université Paris Descartes, EA 4064, Laboratoire de Santé Publique et Environnement, 4, Avenue de l'Observatoire, 75006 Paris, France.
³ Université Paris Descartes, EA 4064, Laboratoire de Santé Publique et Environnement, 4, Avenue de l'Observatoire, 75006 Paris, France.
⁴ Centre des Matériaux des Mines d'Alès, Ecole des Mines d'Alès, Pau, France.
⁵ Université Paris Descartes, EA 4064, Laboratoire de Santé Publique et Environnement, 4, Avenue de l'Observatoire, 75006 Paris, France
⁶ Université Paris Descartes, EA 4064, Laboratoire de Santé Publique et Environnement, 4, Avenue de l'Observatoire, 75006 Paris, France; AP-HP, Hôpital Bichat, Biochimie, Paris, France.

The exposure to gaseous pollutants at the air-liquid interface shows an effect on the respiratory tract. The repeated exposition enables a model that gets closer to physiologically relevant conditions. Inflammatory marker IL-6 and IL-8, cellular viability and cytokine production were assessed.

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Volume 55, Issue 8, Article first published online: 2 JUN 2014 (doi: 10.1002/em.21876)

Authors
Damien Breheny¹, Fiona Cunningham¹, Joanne Kilford², Rebecca Payne², Deborah Dillon¹ and Clive Meredith¹

¹ British American Tobacco, Group R&D, Southampton, Hampshire, United Kingdom
² Covance Laboratories Ltd, North Yorkshire, United Kingdom

Demonstration of the suitability of the VC 10® exposure system for the assesment of the mutagenic potential of gases using the AMES Assay. Not only cigarette smoke, also a wide range of gaseous compounds and aerosol mixtures can be studied.

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International scientists from Europe, Japan, Korea and USA followed the invitation of VITROCELL® Systems to the 2014 User Group Meeting in the Europa-Park Rust, Germany.

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The new module with 6 cell culture compartments is a compact solution for exposure using 6-well, 12-well or 24-well sized inserts.

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24-27 March, 2014

Authors
Ingeborg M. Kooter¹, Mariska Grollers-Mulderij¹, Maaike Steenhof¹, Evert Duistermaat², Frederique van Acker², Yvonne Staal², Eric Schoen¹, Rob Stierum¹, Linette Pellis¹, Frieke Kuper¹

¹ The Netherlands Organisation for Applied Scientific Research, TNO, Zeist, The Netherlands
² TNO Triskelion, Zeist, the Netherlands

Exposition of nano and macro particles on 3D lungcell models in comparison to normal lung cell lines in the air-liqid interface. Differentially effects are shown in the endpoints HO1, IL8, LDH, Comet Assay and gene expression.

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