Advanced in vitro exposure systems.

Lung Cell Exposure to Secondary Photochemical Aerosols Generated From OH Oxidation of Cyclic Siloxanes

28. Feb. 2020

DOI: 10.1016/j.chemosphere.2019.125126 

Autors

Benjamin M King 1 , Nathan J Janechek 1 , Nathan Bryngelson 1 , Andrea Adamcakova-Dodd 2 , Traci Lersch 3 , Kristin Bunker 3 , Gary Casuccio 3 , Peter S Thorne 2 , Charles O Stanier 4 , Jennifer Fiegel 5 

1Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA.
2Department of Occupational and Environmental Health, The University of Iowa, 145 N. Riverside Dr., Iowa City, IA, 52242, USA.
3RJ Lee Group, 350 Hochberg Road, Monroeville, PA, 15146, USA.
4Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA. Electronic address: charles-stanier@uiowa.edu.
5Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA. Electronic address: jennifer-fiegel@uiowa.edu.

 

A549 Lung cells were exposed to the secondary organosilicon aerosols using the Vitrocell 6 air-liquid interface system.

Abstract 
To study the fate of cyclic volatile methyl siloxanes (cVMS) undergoing photooxidation in the environment and to assess the acute toxicity of inhaled secondary aerosols from cVMS, we used an oxidative flow reactor (OFR) to produce aerosols from oxidation of decamethylcyclopentasiloxane (D5). The aerosols produced from this process were characterized for size, shape, and chemical composition. We found that the OFR produced aerosols composed of silicon and oxygen, arranged in chain agglomerates, with primary particles of approximately 31 nm in diameter. Lung cells were exposed to the secondary organosilicon aerosols at estimated doses of 54-116 ng/cm2 using a Vitrocell air-liquid interface system, and organic gases and ozone exposure was minimized through a series of denuders. Siloxane aerosols were not found to be highly toxic. 

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