DOI 10.1186/s12989-015-0104-6

Linda C. Stoehr^1,2†, Carola Endes^3†, Isabella Radauer-Preiml¹, Matthew S. P. Boyles¹, Eudald Casals⁴, Sandor Balog⁵, Markus Pesch², Alke Petri-Fink³, Barbara Rothen-Rutishauser³, Martin Himly¹, Martin J. D. Clift³ and Albert Duschl^1*

²Grimm Aerosol Technik GmbH & Co. KG, Ainring, Germany.
³BioNanomaterials, Adolphe Merkle Institute, Université de Fribourg, Fribourg, Switzerland.
⁴Institut Català de Nanotecnologia (ICN), Bellaterra, Spain.
⁵Soft Matter Scattering, Adolphe Merkle Institute, Université de Fribourg, Fribourg, Switzerland.
* Correspondence: albert.duschl@sbg.ac.at

The use of fluorescence-based reporter cell lines can provide a useful tool in screening the pro-inflammatory response following NP exposure in the air-liquid interface. The results are shown in the IL-8 assay, qRT-PCR ans ELISA.

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Authors

Emilie RICQUEBOURG, Gabrielle VERNOUILLET, Isabelle MOMAS, Nathalie SETA, Sophie ACHARD

Public Health and Environment Laboratory, EA4064 - Paris Descartes University

Exposure of airborne pollutants to a 3D airway epithelial cell modell in the air-liquid interface to measure the epithelial thickness and the inflammatory respone with the IL-8 assay.

Winner of the price "AstraZeneca Young Investigator Prize for Innovation in Drug Discovery and Development"

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DOI:10.1016/j.tiv.2015.05.018

Louise Neilson^a, Courtney Mankus^b, David Thorne^a, George Jackson^b, Jason DeBay^b, Clive Meredith<sup>a

a</sup> British American Tobacco, Group Research and Development, Regents Park Road, Southampton, Hampshire SO15 8TL, United Kingdom
^b MatTek Corporation, 200 Homer Avenue, Ashland, MA 01721, United States

The presentation of a new highly differentiated 3D airway culture, grown and exposed in the VITROCELL® system, shows an successful compatibility of the tissue and the VITROCELL® system for testing e-cigarettes. The results are shown with the MTT assay for cell viability and measurement of TEER.

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DOI: 10.1371/journal.pone.0126536

Authors

Sebastian Oeder , Tamara Kanashova , Olli Sippula , Sean C. Sapcariu , Thorsten Streibel , Jose Manuel Arteaga-Salas , Johannes Passig , Marco Dilger, Hanns-Rudolf Paur, Christoph Schlager, Sonja Mülhopt, Silvia Diabaté, Carsten Weiss, Benjamin Stengel, Rom Rabe, Horst Harndorf, Tiina Torvela, Jorma K. Jokiniemi, Maija-Riitta Hirvonen, Carsten Schmidt-Weber, Claudia Traidl-Hoffmann, Kelly A. BéruBé, Anna J. Wlodarczyk, Zoë Prytherch, Bernhard Michalke, Tobias Krebs, André S. H. Prévôt, Michael Kelbg, Josef Tiggesbäumker, Erwin Karg, Gert Jakobi, Sorana Scholtes, Jürgen Schnelle-Kreis, Jutta Lintelmann, Georg Matuschek, Martin Sklorz, Sophie Klingbeil, Jürgen Orasche, Patrick Richthammer, Laarnie Müller, Michael Elsasser, Ahmed Reda, Thomas Gröger, Benedikt Weggler, Theo Schwemer, Hendryk Czech, Christopher P. Rüger, Gülcin Abbaszade, Christian Radischat, Karsten Hiller, Jeroen T. M. Buters , Gunnar Dittmar , Ralf Zimmermann
Institutes

Exposition of Heavy Fuel Oil and Diesel Fuel Shipping Emissions on human lung cells in the air-liquid interface exposure system for advanced chemical analysis combined with transcriptional, proteomic and metabolomic profiling and isotope labelling methods.

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New MatTek application note shows a state-of-the-art in vitro set up by VITROCELL® Systems for testing combustion cigarettes as well as electronic cigarettes with the endpoints toxicity, oxidative stress, TEER, beating cilia, gene expression and mucus secretion.

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