Advanced in vitro exposure systems.

11. Mar. 2018

VITROCELL® 6/48: Changeover set for 24-well sized inserts

User Group Meeting 2018

Tobias Krebs

VITROCELL Systems GmbH, 79183 Waldkirch, Germany 

 

The poster shows the VITROCEL® 48 exposure system with a 6- and a 24-well setup.

Read more

Comments (0) Number of views (206)

11. Mar. 2018

New design of Monitor Software

User Group Meeting 2018

Johannes Sood
VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The poster demonstrates the new VITROCELL® Monitor software interface.

 

Read more

Comments (0) Number of views (208)

Categories: Publications

Tags: microbalance, photometer

11. Mar. 2018

VITROCELL® Powder Chamber

User Group Meeting 2018

Katharina Knoth1, Marius Hittinger1, Tobias Krebs2

1PharmBioTec GmbH, Science Park 1, 66123 Saarbrücken, Germany  

2VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The poster shows two customer examples for exposures to smallest quantities of dry powders.

 

Read more

Comments (0) Number of views (252)

11. Mar. 2018

VITROCELL® Cloud SEQ

User Group Meeting 2018

Patrick Weindl, Oliver Wisser

VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The VITROCELL® Cloud SEQ represents another evolution of the well-known Cloud systems. Keeping functional process parameters according to established devices like the VITROCELL® Cloud 6, 12 or 24 it is meant to enhance those devices even further. lt offers the possibility to sequentially expose rows of inserts to create dose-response curves while keeping the concentration of nebulized liquid at the same level and the cell-cultures under highly comparable conditions.


 

Read more

Comments (0) Number of views (244)

11. Mar. 2018

VITROCELL® VC 1 Smoking Machine with Shisha Option

User Group Meeting 2018

Markus Berger, Marco Hebestreit

VITROCELL Systems GmbH, 79183 Waldkirch, Germany

The Poster shows a demonstration of the VC 10 smoking machine with Shisha option


 

Read more

Comments (0) Number of views (296)

11. Mar. 2018

In vitro model for the prediction of respiratory sensitization of inhaled chemicals and protein allergens.

User Group Meeting 2018

Chary A.1,2, Serchi T.1, Cambier S.1, Moschini E.1, Contal S.1, Hennen J.2, Ezendam J.3, Blömeke B.2, Gutleb A.C.1
1 Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), Luxembourg.
2 Department of Environmental Toxicology, Trier University, Germany. 3Centre for Environmental Protection,National Institute for Public Health and the Environment (RIVM), The Netherlands.

Aim
- Adapt a 3D-coculture system previously developed by us (Klein et al. 2013) allowing the study of respiratory sensitization processes by including dendritic cells, which have a crucial role in sensitization
- Find markers for the assessment of the respiratory sensitizing potential of inhaled compounds by measuring the activation of DCs as well as the release of cytokines

 

Read more

Comments (0) Number of views (336)

11. Mar. 2018

Elucidating the impact of nanomaterials on genomic stability using high-throughput RT-qPCR and Alkaline Unwinding

User Group Meeting 2018

Matthias Hufnagel, Prof. Dr. Andrea Hartwig 

KIT - Karsruhe Institute of Technology

The poster shows the establisment of the use of a high-throughput RT-qPCR method and the quantitative detection of DNA strand breaks (Alkaline Unwinding) for cells exposed in the Air-Liquid Interface.

Read more

Comments (0) Number of views (214)

11. Mar. 2018

The use of human 3D reconstructed bronchial tissue to study the effects of cigarette smoke and e-cigarette aerosol on a wide range of cellular endpoints

SOT 57th Annual Meeting, 11 –15th March 2018

Lukasz Czekala1, Matthew Stevenson1, Liam Simms1, Nicole Tschierske1, Anna G. Maione2, Tanvir Walele3
1 Imperial Tobacco Ltd, 121 Winterstoke Road, Bristol, BS3 2LL UK
2 MatTek, 200 Homer Ave., Ashland, MA, USA
3 Fontem Ventures B.V., an Imperial Brands PLC Company, Radarweg60, 1043 NT Amsterdam

A 3D in vitro organotypic model of the human respiratory epithelium was cultured at the Air-Liquid Interface (ALI) and exposed to cigarette smoke and e-cigarette aerosol, generated by using a VITROCELL® VC1 smoking machine under Health Canada Intense and CORESTA conditions.
The results are shown in tissue viability (MTT), barrier integrity (TEER), Barrier function, tissue secretion of the pro-inflammatory cytokines (IL-6 and IL-8). The presence of 8-isoprostane is used as an indicator of oxidative stress and antioxidant deficiency. Additionally the tissue morphology was assessed by H&E staining and immunofluorescent staining was conducted for specific markers.


Read more

Comments (0) Number of views (534)

1. Mar. 2018

Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment

https://doi.org/10.1016/j.fct.2018.02.063
Anita R. Iskandar, Florian Martin, Patrice Leroy, Walter K. Schlage, Carole Mathis, Bjorn Titz, Athanasios Kondylis, Thomas Schneider, Grégory Vuillaume, Alain Sewer, Emmanuel Guedj, Keyur Trivedi, Ashraf Elamin, Stefan Frentzel, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
PMI R&D, Philip Morris Products S.A., Part of Philip Morris International group of companies, Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland


Highlights
• Aerosols of a heat-not-burn tobacco product elicited lower impacts compared with smoke of 3R4F reference cigarettes.
• Systems toxicology revealed changes at the cellular–molecular levels not otherwise apparent from morphological features.
• The reduced impact of heated tobacco aerosols on small airway was similar than that on nasal epithelial cultures.

Read more

Comments (0) Number of views (374)

1. Feb. 2018

Comparative Effect of a Candidate Modified Risk Tobacco Product Aerosol and Cigarette Smoke on Color Stability of Enamel, Dentin and Dental Composite Resins

SRNT 2018

Filippo Zanetti1, Xiaoyi Zhao2,3, Shoaib Majeed1, Hans Malmstrom2, Manuel C. Peitsch1, Yanfang Ren2, Julia Hoeng1

1 PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland (part of Philip Morris International group of companies)
2
University of Rochester Eastman Institute for Oral Health
, Rochester, New York
3
Peking University School of Stomatology
, Peking, China

In this study, the effects of 3R4F cigarette smoke and THS2.2 aerosol on color stability and surface roughness of premolar human teeth were investigated.

The poster was presented at SRNT 2018, https://www.srnt.org/

Read more

Comments (0) Number of views (481)
RSS
12345678910Last
Back to Top