Modules for 6-well sized inserts
The VITROCELL® 6/6 module system has been specifically designed and engineered to facilitate the research of mammalian cell cultures in direct exposure to airborne substances such as gases, complex mixtures, nanoparticles and fibers. The system authentically simulates the conditions of human physiological exposure.
Adaptors for 12 and 24-well sized inserts make this exposure system a universal testing platform for multiple applications.
Each row of 3 culture compartments has an independent medium inlet. The level of medium can be monitored externally for additional control. Temperature is electronically controlled at 37° C (99° F) by means of a heated base plate. Therefore, an additional incubator is not required while using this module. The base module is made of electropolished stainless steel. It is autoclavable at 121° C (250° F) for 20 min.
Special sealing and connection mechanisms guarantee a hermetic connection of the base module with the aerosol exposure top.
The aerosol inlet-stream flows through specifically shaped inlets. They are available in stainless steel or stainless steel with unique VITROGLIDE surface treatment for lowest adhesion results. The stainless steel / VITROGLIDE inlets are specifically designed for aerosols containing nanoparticles.
The aerosol inlets are connected to the distribution or dilution systems. Extraction from the module takes place via small holes using a controlled vacuum flow. VITROCELL® calibration valves, which are connected to a vacuum pump control flow rates effectively. The aerosol exposure top features an in/outlet for heating the water circuit, ensuring corresponding temperatures with the base module. It is made of high-quality anodized aluminum.
A choice of modules equipped with 1 Quartz Crystal Microbalance for dose monitoring is also available.
Universal module with optional adaptor sets for:
All commercial brands are supported.
VITROCELL® exposure systems have been specifically designed and engineered to give researchers the possibility of directly exposing mammalian cells or tissue at the air/liquid interface. Thus, all cell types cultivated on microporous membranes can be used. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
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