It offers a capacity of up to 18 cell culture compartments for exposure and 6 compartments for clean air control.
All key functions for successful exposure such as, aerosol flow rates, humidity, temperature and leak test are edited by touch-screen prior to the experiment. The respective data is shown on live graphs and stored for further analysis. The cells are exposed at the air/liquid interface on 6/12/24-well sized cell culture inserts.
The isokinetic sampling system enables a uniform and reproducible delivery of the test substance to the cells. Applying an electrical field increases deposition efficiency.
Post-exposure the cells are further processed to measure a wide range of endpoints, e.g. cytotoxicity, genotoxicity, proliferation, cellular and oxidative stress as well as inflammation. See also the VITROCELL® assay guide for further information.