○ Fully automated row-by-row exposure of 12-, 24- and 96-well sized cell culture inserts ○ Aerosolisation defined by nebulization time or volume ○Integrated controller for aerosol generator ○Optional integrated microbalance controller ○Programmable experiment recipes ○Output rate database for nebulizers ○Heating system ○ PowerVent function: evacuation of residual aerosols via vacuum pump ○ Designed for screening of inhaled drugs, toxicity testing of inhaled substances such as chemicals or nanoparticles and virus research Features Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems 96-well: 12 Individual Doses Sequential Exposure of Corning® HTS Transwell® 96-Well Permeable Support Systems in up to 12 steps @8 replicates. 24-well: 6 Individual Doses Sequential Exposure of 24-well sized culture inserts in up to 6 steps @4 replicates. 12-well: 4 Individual Doses Sequential Exposure of 12-well sized culture inserts in up to 4 steps@3 replicates. For each of the exposures applies: After each nebulization the exposure chamber is automatically evacuated by vacuum pump to enable equal exposure conditions for the following nebulisation. Dosimetry using Quartz Crystal Microbalance (QCM) The QCM sensor is integrated in the Cloud Alpha MOVE exposure module. It is capable of measuring the deposited mass in nanogram/cm2. Results are recorded in the VITROCELL® Monitor software. Data is presented in graphs and stored in MS Excel® 71
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