VITROCELL Systems

Phase 2 Homogeneous Mixing Single droplet sedimentation Phase 3 Gravitational Settling Skin Exposure Auxiliary Equipment Dose Monitoring Racks & Carts Dilution Dose Supply Exposure Systems The QCM sensor is integrated in the Cloud Alpha MAX exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL® Monitor software. Data is presented in graphs and stored in MS Excel ®. Dosimetry using Quartz Crystal Microbalance (QCM) The system comes with a choice of 3 types of vibrating mesh nebulizers having droplet MMAD ranges of ○ 2.5 – 4.0 µm ○ 2.5 – 6.0 µm ○ 4.0 – 6.0 µm Recommended nebulisation volumes are 10 – 40 µl. So the device is par ticularly suitable for testing whenever small quantitities of testing materials are available. Choice of three types of nebulizers ○ Lowest nebulization volumes: ≤ 40 µl per exposure and well ○ High deposition efficiency ○ Cloud dynamics by vibrating mesh nebulizers ○ Easy handling with no external air-flow required ○ High reproducibility ○ Air Liquid Interface (ALI) exposure ○ Direct and efficient guidance of substance exposure to the cells ○ 80, 40, 10 mm tube length Features Phase 1 Emission Of Cloud Af ter pipetting the suspension, exposure to the cell cultures takes place in three phases: How the Vitrocell ® Cloud works 69

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