VITROCELL Systems

VITROCELL® Cloud 12 For exposure of cell cultures to liquid aerosols at the Air/Liquid Interface The VITROCELL® Cloud Alpha 12 is our new innovation in the Cloud family and presents a great leap forward in automated exposure of cell cultures. It combines high deposition efficiency with ease of use. The development is based on the well-known and frequently published VITROCELL® Cloud formats (6-, 12- and 24-well) of the first generation. It ’s functionality enables fully automated processes with an all-in-one control unit . Everyday experiments at the Air/Liquid Inter face have never been easier. The new Cloud Alpha 12 was developed as a result of numerous customer requests and is capable to expose mammalian cell cultures in 12- or 24-well sized cell culture inser ts. All commercial brands are suppor ted. The Cloud system is suitable for nebulization of solutions and suspensions. Fields of application are virus research, screening of inhaled drugs and toxicity testing of inhaled substances such as chemicals or nanopar ticles. The system has an integrated controller for the aerosol generator, adjustable via touchscreen. The QCM sensor is integrated in the Cloud Alpha 12 exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL® Monitor software. Data is presented in graphs and stored in MS Excel ®. Dosimetry using Quartz Crystal Microbalance (QCM) Inser t holders for 12- and 24-well sized inser ts are par t of the delivery. All commercial brands are suppor ted. Insert holder system 62

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