Advanced in vitro exposure systems.

Nanoparticles on human lung cells

16. Jun. 2016

The Vitrocell Exposure System for cell cultures at the air-liquid interface

Sonja Mülhopt1, Tobias Krebs2, Dr Silvia Diabaté3, Christoph Schlager1, Dr Hanns-Rudolf Paur1

1 Institute for Technical Chemistry, Karlsruhe Institute of Technology, 
2 Vitrocell Systems GmbH, 
3 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology

 

This article shows the development of an automated exposure system which allows both reproducible sampling and conditioning of aerosols and exposure of the cell cultures under conditions imitating those of the human lung. Bioassays were developed and used for toxicological analysis of particulate emissions from the industry as well as of nanoparticles.

The health effects of airborne nano- and microparticles are discussed controversially. The fully automated Vitrocell Exposure Station was developed to evaluate the effects of these aerosols through bioassays with human lung cell cultures. The system allows to reproducibly apply aerosols to the cells to analyze the biological effects.

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