Advanced in vitro exposure systems.

Comet assay and air-liquid interface exposure system: A new combination to evaluate genotoxic effects of cigarette whole smoke in human lung cell lines

6. Sep. 2013

Toxicology in Vitro

Volume 27, Issue 6, September 2013, Pages 1987-1991. pii: S0887-2333(13)00168-9. doi: 10.1016/j.tiv.2013.06.016. [Epub ahead of print]

Authors
Weber S.1, Hebestreit M.1,3, Conroy L.L.1, Rodrigo G.2

1 Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstr.3, 51149 Cologne, Germany
2 Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland
3 Current address: VITROCELL Systems GmbH, Germany

 

Human lung cell lines A549 and BEAS-2B were exposed to diluted whole smoke in the VITROCELL® 24 and DNA damage was evaluated using the comet assay.

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