Advanced in vitro exposure systems.

Biological effects in human lung cells exposed to platinum nanoparticle aerosol

11. Sep. 2009

European Aerosol Conference. Karlsruhe, Germany.

September 06-11, 2009

Authors
S. Diabaté, C. Weiss, S. Mülhopt, H.-R. Paur, V. Niedetzky, M. Seipenbusch

Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, 76021, Karlsruhe, Germany
Institute for Technical Chemistry, Forschungszentrum Karlsruhe, 76021, Karlsruhe, Germany
Institute for Mechanical Process Engineering and Mechanics, University Karlsruhe, 76131, Karlsruhe, Germany

 

For the bioassay they exposed platinum nanoparticles to BEAS-2B and A549 cells, both co-cultured with differentiated THP-1 macrophages, growing on Transwell inserts. The responses of the cells were analyzed by measuring the viability, LDH and IL-8. 

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