Advanced in vitro exposure systems.

An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke

25. Feb. 2003

URBAN & FISCHER

Exp Toxic Pathol 2003; 55: 51-57

Authors
Michaela Aufderheide, Jan W. Knebel, and Detlef Ritter

 

The study presented a system that enables the direct exposure of human lung cells to native, unmodified cigarette mainstream smoke and also the demonstration of reproducible particle deposition depending on smoke concentration. Furthermore, it was shown that the exposed cells maintained their viability. The results were shown in measuring the cellular viability, ATP and glutathione content. 

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