Advanced in vitro exposure systems.

An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung

26. Jul. 2013

Particle and Fibre Toxicology 2013, 10:31

doi:10.1186/1743-8977-10-31

Authors
Sebastian G Klein12, Tommaso Serchi1, Lucien Hoffmann1, Brunhilde Blömeke2 and Arno C Gutleb1*

1 Department Environment and Agro-biotechnologies (EVA), Centre de Recherche Public - Gabriel Lippmann, 41 rue du Brill, L-4422 Belvaux, Luxembourg
2 Department of Environmental Toxicology, University of Trier, Universitätsring 15, Trier, Germany

 

Exposition of fine and ultra-fine particles on a tetraculture of A549, TPA-1, HCM-1 and EA.hy 926 cells to measure oxidative stress with the IL-8 and DCFH-DA assay.

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