Advanced in vitro exposure systems.

VITROCELL® Photonion

Microbalance Sensors & Software

Photonion has developed a new on-line real-time measuring system for chemical gas analysis based on time-of-flight mass spectrometry (TOF-MS). This technology is now integrated in the VITROCELL® modules in order to analyse the sampling at the spot where the cells are exposed.

Three different ionization techniques are applicable:

  • single photon ionization (SPI) with a special VUV
  • excimer source or laser VUV source
  • resonance enhanced multiphoton ionization (REMPI) with a laser beam
  • electron impact ionization (EI).

SPI and REMPI are considered as soft ionization techniques allowing the acquisition of mass spectra with nearly no fragmentation. A heated transfer line allows direct gas analysis of e. g. engine exhaust, cigarette smoke or e-cigarette vapors.

Gaseous samples are addressed continuously by the Photo-TOF-MS mass spectrometry system at a flow rate of approx. 2mL/min. Depending on the ionization technique various relevant species can be ionized by SPI, REMPI or EI. After the ionization, the formed ions are accelerated into the reflectron time-of-flight mass analyzer where they are separated due to their different mass to charge ratios.

A typical TOF mass spectrum can be generated in some milliseconds.This fast on-line measurement system is a selective and sensitive analytical method to investigate complex gas mixtures such as from combustion processes.

Technical Data

TOF-mass analyzer
  • Direct reflection time of flight mass spectrometer (flight path 0.9 m)
  • Mass range: 10 – 2000 Th (m/z) (standard configuration)
  • Mass resolution: m/Δm = 2000
  • Linear dynamic range: 104
  • Mass accuracy: 100ppm
  • Maximal primary data acquisition rate: 100 kHz
Rack configuration
  • 2x19”-module rack
  • Dimensions 1.200 x 800 x 1.300 mm (W x D x H)
  • Power supply 100-230V, 50/60Hz
Data acquisition and visualization software
  • data is displayed in real time
  • actual measured mass spectra and the variation of selected ions is displayed
  • Data can be exported (formats e.g.: txt, CSV)
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